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The 11 Most Popular Prescription Drugs in the U.S.

A man holding a prescription bottle.
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We all know what’s in our medicine cabinet — but how do it compare with others?

The American Society of Health-System Pharmacists recently used data from drug manufacturers to determine the most popular prescription drugs in the U.S. based on how much was spent on them in 2023.

Some trends stood out. Weight-loss drugs were the main drivers of a 13.5% increase in prescription drug spending in the U.S. Tizepatide, a drug initially for treating diabetes, grew 373% in popularity even though the U.S. Food and Drug Administration (FDA) did not approve it for weight loss until late 2023. At the same time, hospital spending on prescription drugs decreased by 1.1% in 2023.

The American Society of Health-System Pharmacists speculates that the amount spent on weight-loss drugs will continue to increase as supply catches up with the growing demand.

The following prescription drugs are those that the U.S. collectively spent more than $10 billion on — per drug — in 2023. That includes spending at pharmacies, clinics and hospitals.

11. Risankizumab

Senior man taking pills
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Common brand name(s) for this drug: Skyrizi

Amount spent on this drug: $10.1 billion in 2023

Risankizumab can be taken as either an injection or a pill. It’s used to treat moderate to severe plaque psoriasis (an autoimmune skin condition) in adults whose psoriasis can’t be treated by topical medications alone. It’s also prescribed for adults with psoriatic arthritis and Crohn’s disease (a type of inflammatory bowel disease that’s also autoimmune).

10. Dupilumab

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Common brand name(s) for this drug: Dupixent

Amount spent on this drug: $11.49 billion in 2023

Dupilumab is an injection given to people with eczema (a skin condition) who cannot use, or haven’t responded to treatment from, other medications. It’s also used to treat symptoms of certain types of asthma.

9. Bictegravir/emtricitabine/tenofovir alafenamide

Patient smiling at his doctor
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Common brand name(s) for this drug: Biktarvy

Amount spent on this drug: $13.15 billion in 2023

The combination of bictegravir, emtricitabine and tenofovir alafenamide is used to treat human immunodeficiency virus (HIV) infection. It doesn’t cure HIV but may lessen the risk of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses like serious infections or cancer.

8. Tirzepatide

A man smiling after losing weight.
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Common brand name(s) for this drug: Mounjaro, Zepbound

Amount spent on this drug: $13.16 billion in 2023

Zepbound was approved by the FDA in November 2023 for weight management in adults with obesity and overweight adults with at least one weight-related condition, like high blood pressure, Type 2 diabetes or high cholesterol. Tirzepatide is not a new medication, however. This injection was first used under the brand name Mounjaro, and still is, to treat Type 2 diabetes.

7. Pembrolizumab

Patient talking to her doctor while sitting on an exam table
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Common brand name(s) for this drug: Keytruda

Amount spent on this drug: $15.4 billion in 2023

Pembrolizumab is an injection used to treat types of skin cancer, including melanoma, Merkel cell carcinoma and cutaneous squamous cell carcinoma. It can be used, either alone or in conjunction with chemotherapy, to treat other forms of cancer.

6. Ustekinumab

Arthritis pain
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Common brand name(s) for this drug: Stelara

Amount spent on this drug: $15.87 billion in 2023

Ustekinumab is used to treat the signs and symptoms of active psoriatic arthritis, like psoriasis and joint swelling. It’s also used to treat plaque psoriasis and moderate to severe Crohn’s disease. It’s an injection.

5. Empagliflozin

Jardiance prescription drug tablets
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Common brand name(s) for this drug: Jardiance

Amount spent on this drug: $15.89 billion in 2023

Empagliflozin is used to lower blood sugar levels in people with Type 2 diabetes, as well as to reduce the risk of stroke, heart attack or death in people who have both Type 2 diabetes and a heart and blood vessel disease.

It may also be prescribed to lower the risk of cardiovascular death and hospitalization for patients with heart failure, and to lower the risk of worsening kidney disease.

4. Dulaglutide

Trulicity
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Common brand name(s) for this drug: Trulicity

Amount spent on this drug: $16.28 billion in 2023

Dulaglutide is an injection taken once a week to treat Type 2 diabetes. It’s meant to not only affect insulin levels, but also to help reduce the risk of heart attack and stroke in people with Type 2 diabetes.

3. Apixaban

Eliquis prescription drug tablets
Raihana Asral / Shutterstock.com

Common brand name(s) for this drug: Eliquis

Amount spent on this drug: $22.11 billion in 2023

Apixaban is prescribed to treat or prevent deep venous thrombosis (blood clots in deep veins, often in the legs). These blood clots are at risk of traveling to and lodging themselves in the lungs, which can cause pulmonary embolism (a blockage in the lungs). It may also be used to help prevent strokes and blood clots in patients with certain heart rhythm problems.

2. Adalimumab

Humira prescription drug injection
Lea Rae / Shutterstock.com

Common brand name(s) for this drug: Humira

Amount spent on this drug: $35.33 billion in 2023

Adalimumab is used to treat various autoimmune conditions, including rheumatoid arthritis, psoriasis, psoriatic arthritis, plaque psoriasis, Crohn’s disease and ulcerative colitis (a type of inflammatory bowel disease).

1. Semaglutide

Ozempic
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Common brand name(s) for this drug: Ozempic, Rybelsus, Wegovy

Amount spent on this drug: $38.58 billion in 2023

Under the brand name Ozempic, semaglutide is an injection used to treat Type 2 diabetes and to reduce the risk of a stroke, heart attack or death in adults who have both Type 2 diabetes and a heart and blood vessel disease. Under the brand name Wegovy, the injection was subsequently approved as a weight loss drug in 2021 and can help suppress appetite. Semaglutide has soared in popularity because of its weight-loss properties.

Rybelsus is a tablet form of semaglutide used to improve blood sugar levels in people with Type 2 diabetes.

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